Rapamycin Dosing & DIet – Rapamycin Longevity Information

Hello all,

Given {that a} vegan weight loss plan doesn’t activate mtor to the identical extent as a meat based mostly weight loss plan, I’m considering it might be the case that meat-eaters want increased ranges of rapamycin than the vegan. If that is true, then I’m questioning what downward dose changes can be acceptable for the vegan to get the identical stage of anti-aging advantages whereas avoiding unintended effects.

I’ve diminished my consumption of rapa over the previous few months from 6 mg / wk to three mg each 9 days on this foundation (I’ve had a pair pores and skin infections w/ the upper dose.) I’m questioning if it’s prone to be the vegan weight loss plan that makes 6 mg per week extreme for me. Anybody have any ideas?

Thanks
Jim

Proper now there’s not a lot scientific information behind the present dosing or optimum dosing for longevity. The overall thought of dosing round 5mg, in a single dose weekly comes largely from information supplied in the 2014 Mannick rapalog trial paper.

However this was simply targeted on immune perform within the aged, not slowing down growing older usually. The mouse research within the ITP program have been profitable in lifespan enchancment with a lot increased doses (in a dose dependent method), however individuals aren’t mice and we don’t stay in pathogen free environments.

However even with the Mannick trial, they didn’t modify for weight (sometimes bigger individuals require a better dose for a similar impact), and different variables.

I’m speaking with a rapamycin researcher later this week so I’ll see if I can get some insights on the science behind your query…

It may very well be linked. I’ve been a vegetarian for just a few a long time. And could also be due to that I want a a lot smaller dose than different individuals to have the identical outcomes. If I by chance take even 1mg over my common dose, I might have disagreeable unintended effects. It by no means occurred to me that my veggie weight loss plan and Rapa dosing might work synergetically.

Thanks for having introduced collectively this priceless website and group! Would love to listen to any ideas on this matter additionally.

And maybe additionally when you, the researcher and/or others have any ideas on interactions with say a quarterly 5 day water solely quick — good to skip rapa that week or as a substitute go for the mixed (synergistic?) impact of each on that when 1 / 4 event?

Thanks! I’d be actual curious to listen to what they are saying.

If the 0.5 mg / day 5 mg / week, 20 mg / week everolimus research is the premise for rapamycin protocols, shouldn’t the usual rapa dose be 2.5 mg per week? (If one dose of everolimus is equal to half a dose rapa).

Maybe – in concept, however I believe Dr. Inexperienced and others who first actually began human adoption of rapamycin most likely appeared on the ITP outcomes and determined to extend the dose upwards.

The 2014 Mannick Examine didn’t do a 10mg dosing, they did 5 and 20mg. I believe typically the docs like Alan Inexperienced are considering that the 10mg would have been dose, so are defaulting on round 6mg rapamycin for individuals.

This pertains to the broader situation of “dosing heuristics” – I like to recommend you learn this dialogue right here: What’s the Rapamycin Dose / Dosage for Anti-Ageing or Longevity? – #196 by AJD