Rapamycin for Eyes – Rapamycin Longevity Information

I’m curious whether or not the retinal blood barrier might act as a proxy measure for the blood mind barrier.
And thus the rapamycin impression on retinal well being/operate would possibly act as a proxy for mind impression?

I ask as a result of i personally have very detailed 6 month-to-month ophthalmology knowledge because of a threat of early onset glaucoma. And so it will likely be attention-grabbing to see if my rapa protocol makes any measurable impression once I’m subsequent examined.

Curious if anybody has any ideas. On rapa and the retina

Evaluate the next beneath, posted on one other thread about 1 week in the past

Thanks. I had and I believe it referred to injections solely. Have you learnt of any topical (eye drops) or oral therapy research for eye well being with rapamycin?

Simply had look and this appears nice: The topical ocular supply of rapamycin to posterior eye tissues and the suppression of retinal inflammatory illness – ScienceDirect

Fascinating… I’d not heard of this analysis:

On this work, now we have formulated a mannequin compound, rapamycin(RAP), in nanoparticle-based eye drops and evaluated the supply of RAP to the posterior eye tissues in a wholesome rabbit.

The topical software of the MET-RAP eye drops to the EAU mouse mannequin resulted in important illness suppression in comparison with controls, with exercise just like dexamethasone eye drops. The MET-RAP eye drops additionally resulted in a discount of RORγt and a rise in each Foxp3 expression and IL-10 secretion, indicating a mechanism involving the inhibition of Th17 cells and the up-regulation of T-reg cells. The MET-RAP formulation delivers RAP to the posterior eye segments, and the formulation is energetic in EAU.

Please tell us if you happen to determine to experiment with rapamycin eye drops. Many people are already utilizing DIY rapamycin toothpaste: DIY Rapamycin Toothpaste and Flossing Paste and rapamycin pores and skin cream: DIY Rapamycin pores and skin cream

Extra info on Rapamycin and Eyes:

mTOR inhibitors: A brand new class of therapeutics.

Sure I’ll. My preliminary curiosity although is whether or not systemic rapa (from oral) has any impression

I discovered one examine (retrospective and solely n=5) which suggests oral sirolimus (and everolimus) have an effect past the retinal blood barrier.

However i can solely entry the summary on my telephone, so I’m unsure what the dosing was.

I’ll admit to experimentation with selfmade rapa eyedrops. I can’t say it has had a noticeable impact, nevertheless it’s solely been a number of months. My motivation is to cut back the speed of improvement in a cataract. I’ve had no unwell results. I exploit 1 mg powdered rapa + 1 drop transcutol per 4 single-use containers/vials. Then I exploit 1 drop a few times a day.

I do know so little about Glaucoma however I’ve to surprise if Insulin Resistance performs some function in it? If that’s the case, decrease your carb consumption and so forth.