Rapamycin for my Cats? – Rapamycin Longevity Information

Then how would you suggest one provides a smaller dose of rapamycin to their cats? I’ve two cats and solely 1mg tablets, so what can be a great way to provide them each 0.5mg with out breaking the tablet?
I considered crushing the capsules down and mixing it in with a few of their moist meals, however now after what you mentioned it appears that evidently it wouldn’t actually do something for them since they are going to have low bioavailability.

What you might need to do is what individuals are doing… dose greater than the usual dosing at one time, however then enhance the time between doses.

Many individuals are taking greater ranges of rapamycin (for instance Bryan Johnson is taking 13mg of rapamycin each two weeks). Bryan Johnson’s Longevity Protocol – Your Ideas?

That is in comparison with the traditional longevity dosing for males of round 6mg , as soon as per week.

There is no such thing as a cause why the identical method couldn’t be utilized in pets: What’s the Rapamycin Dose / Dosage for Anti-Getting old or Longevity?

As a result of my canine is comparatively small (24 lbs) and the tablets are all in 1mg parts, I give my canine 3mg each two weeks or so now.

I ask as a result of the 1mg tablets can be arduous to get the cat to swallow, as an alternative of blending it in meals crushed up/powdered. Its simple for a canine to only swallow it with a deal with, however cats are totally different.

Ah, I believed cats would eat just about the identical approach canine do. My canine, and I feel maybe most canine, actually don’t chew issues a lot. I put the rapamycin tablets inside a small dice of cheese (utilizing a knife to chop a small incision within the facet of the cheese, then tucking the pill inside that incision). My canine principally simply swallows it entire.

I’ve no expertise with cats. Maybe somebody can check this method out, or strive different comparable approaches, and see what works finest, and report again on what doesn’t work and what does work.

Given the well-documented bioavailability points with powdered/unencapsulated rapamycin, I’m fairly positive you don’t simply need to crush the tablets and blend with the meals.

Maybe overlaying the pill with a tasty cat-treat (peanut butter?) may work? Does anybody else have any concepts? The smaller the animal will get, the extra this turns into an issue.

The unique NIA ITP research on rapamycin had been delayed for a lot of months once they first found this bioavailability downside (the rapamycin is destroyed within the abdomen) once they had been beginning the mouse trials. They ended up creating a customized/costly methodology of encapsulating the rapamycin powder (now named E-rapa) in tiny . The rapamycin researchers out of Texas (Rodney Robust and David Sharp) ended up forming a small firm simply to supply this eRapa that was utilized in all of the rapamycin mouse trials.

Since then the corporate appears to have gotten extra funding and try to develop their market – however I spoke with Matt Kaeberlein on the Longevity Summit in December, 2022 about this firm as I noticed that they’re now doing human medical trials with their eRapa product (see right here ) however that appeared a bit of odd to me, as functionally it appears that evidently this model of eRapa is principally the identical because the Rapamune and generic rapamycin tablets that every one had barely totally different strategies of getting across the bioavailability downside. Matt agreed, there didn’t appear to be any purposeful distinction between eRapa and the common human-use rapamycin tablets. Traditionally the important thing advantage of eRapa was that there have been very small granules that had been encapsulated and that could possibly be combined in with mouse chow. However – the corporate fees quite a lot of this product, (very small quantity I’m positive) – so its solely utilized in mouse and different small animal analysis research.

Extra data on the corporate behind eRapa: https://emtorabio.com/

I’m not a cat fan.

However we had cats on meds as a child and we might open their mouths and shove the tablet down with the top of an eraser on a pencil. Labored!

Possibly dose the tablet with a little bit of moist cat meals to make it extra palatable.

Sure? Too imply?

Joyful to say the medical research with rapa on cats with hcm is now finalised and report needs to be accessible quickly. On TriviumVet web site they revealed in the present day a video with Joshua Stern from UC Davis taking about it.

My cat is taking 1 mg tablet with none points in any respect. He swallows is entire with a snack, no chewing. Simple. if regular snacks don’t work, strive simple capsules. 90 p.c of cats will swallow completely every part coated by this malarkey.

How do you give it to him? Any hiding it in meals? Or overlaying it in one thing that tastes good?

I disguise it in a snack. A chunk of cats’ “sausage” stick garbage from grocery store by webbox. Not nice substances however tender sufficient to cover the tablet. And straightforward tablet works wonders, too.

Is that this what you’re speaking about relating to “simple tablet”? I’m not acquainted with it:

Use the tiny quantity. No want to provide so much.

Who cares if you’re not a cat fan?

I’ve one cat who will swallow it entire no downside, and my different one refuses to eat it no matter methodology I strive. He simply wont eat it

You most likely have an answer by now. However, here’s what I exploit:Amazon.com : FELINE GREENIES PILL POCKETS for Cats Pure Mushy Cat Treats
Simply decide the flavour your cats like.

I’ll test it out, thanks! I’m engaged on getting one among my cats to eat it, as he refuses no matter what I strive.

You’ll be able to lead a cat to rapamycin however you may’t make him swallow

Guess we’ll have to attend for the revealed research to verify what dose they really used (I watched and didn’t see any specifics apart from “low dose” and “excessive dose,” and it was said even the excessive dose was decrease than what’s used for different circumstances).

I did discover a patent for Trivium that reveals a number of doses talked about – .15 mg/kg, .45 mg/kg, .75 mg/kg, and three particular pill sizes, .4mg, 1.2mg and a couple of.4mg.