The examine that I linked may be very favorable in the direction of rapamycin results in mice re insulin. Brief time period utilization is dangerous however longer-term utilization turns favorable.
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The day after I learn this I acquired my labs for a PE. Been on on Rapa about three months (2.5mg MWF initially , then 7.5mg as soon as weekly extra lately. Lo and behold, each Whole and Free T 2/3 decrease than six months in the past. I’ve been on HRT for a a number of years (72yo, male) and have had ranges persistently in excessive regular vary for the lab).
My skeletal muscle mass has additionally declined. I practice cardio and energy repeatedly. My coach has famous that since taking rapa, I’ve plateaued in my lifting the place I had been hitting PR’s on a reasonably common foundation.
Going off rapa, and can retest in three months to rule out that variable (the opposite variable being the compounding pharmacy that makes up the cream for topical software; can’t do injections as on anti-coaguant).
PS My doc was blown away by important enchancment in my lipids. WBC/neutrophils down a bit.
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Thanks for sharing this vital data dogdoc!
Please tell us in case your testosterone ranges return to your regular baseline after going off rapamycin for 3 months. Hopefully the obvious detrimental impact of rapamycin on testosterone ranges is reversible.
That’s simply bizarre as a result of in case you are on Trt your endogenous testosterone manufacturing stops which implies that if you happen to didn’t change your Trt dosing schedule your testosterone will get used up or damaged down faster…
Testosterone ranges drop shortly on the finish of the weekly dosing interval. So, day of testing relative to the date of administration could make an enormous distinction.
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To make clear, I’ve been taking testosterone through a compounded topical cream utilized every day which for some years has maintained good ranges of complete and free T. I’ve additionally had my blood attracts three hours post-application as my physician mentioned that must be a peak ranges. I get blood drawn subsequent week to recheck my T which can be seven weeks off rapa (I’m pondering that could be a enough variety of half-lives.) I’m not ruling out the potential for a difficulty with the compounding pharmacy as my preliminary trials with proprietary topicals have been ineffective which is why I ended up utilizing a comounded product. Possibly they’ve modified one thing within the prep of the cream. My present doc doesn’t see a difficulty with getting testosterone by injection. Might get an endo seek the advice of.
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Chances are you’ll select injection for a extra dependable supply of the dose. By the way in which it doesn’t should be IM. Sub cutaneous injection works advantageous and is much less painful though the directions are for IM.
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After 61/2 weeks off rapa, my complete and free T have recuperate to 78% and 75% of pre-rapa ranges respectively. Will recheck within the subsequent few months. Unsure re restarting at any time. The implications of low T are huge ranging, to not point out the direct impact of the elevated catabolism from rapa on skeletal muscle mass, bone density, WBC counts, and so forth . Will search for extra information, each scientific and anecdotal on this subject.
DD
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Thanks dogdoc for the replace. Please preserve us posted. I consider the potential antagonistic results of rapamycin on male testosterone ranges is underappreciated. Rapamycin has been proven to lower the scale of testes in rodents. I think solely a small fraction of males have routinely been testing their complete and free testosterone ranges previous to beginning rapamycin, and repeatedly afterwards.
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@dogdoc do you will have any updates?
