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Could I counsel you learn the enclosure you bought along with your empagliflozin?
First, I don’t have kind 2 diabetes, however I’m previous and my fasting glucose and A1c proceed to slowly rise. My present fasting glucose stage is 97mg/dL and A1/c is 5.5 % of whole Hgb I’ve been on metformin for many years, first 500 mg every day and now 500mg twice every day. Metformin actually has blended critiques for somebody my age. (81) So, I’ve been biking on and off with different blood sugar-lowering dietary supplements to see what impact they’ve on my fasting glucose. I take my blood glucose ranges 2 to three instances a day.
The blood sugar-lowering medicine and dietary supplements I’ve or am taking are metformin, Jardience/Empaglifozin, berberine, and chromium dietary supplements. I just lately began attempting Jardience/Empagliflozin tablets made by a German firm Boehringer Ingelheim and imported to India by Boehringer Ingelheim India Non-public Restricted.
Oddly, not one of the issues I’ve tried or am taking appear to have a lot of an impact on fasting glucose. Empagliflozin taken at 10 mg and 20 mg every day has had no discernible impact. Immediately I lastly took out and browse the Jardiance/Empaglifozin enclosed literature. I used to be shocked on the virtually innumerable uncomfortable side effects they’d listed from comparatively massive cohort research ~70,000. They provide a shocking quantity of details about the drug. Additionally, the profit in comparison with placebo at varied doses and with and with out metformin was not very spectacular.
So at this level, I’m going to forego metformin and empagliflozin as a result of for me the chance vs reward advantages aren’t there.
Backside line: For me personally, metformin, empagliflozin, berberine, and so forth, has had little impact on my blood glucose ranges. For youthful folks there could also be longevity results with the metformin.
i’m 70 and never diabetic, at present taking canagliflozin 50 mg every day (lower 100 mg tablet in half), and 25 mg acarbose on meal instances. my fasting blood glucose drops from 108 in December 2021 to 88 in April this yr. I additionally misplaced 10 kilos weight in between. IMO, the combo works higher than metformin i took earlier than.
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Good for you, although I personally discovered that shedding pounds alone lowers blood glucose.
Properly, presumably in my case, you may’t repair what just isn’t damaged.
Apparently whereas I used to be on a ketogenic eating regimen I found that potassium BHB salts would dramatically drop my blood sugar in half-hour. Individuals on a ketogenic eating regimen are inclined to have a better than regular fasting blood sugar stage. BHB salts had been really useful to assist transition into ketosis. I take advantage of the potassium for 2 causes, I just like the blood pressure-lowering response to the potassium, and two, the potassium salt will be taken in a glass of water as a result of it isn’t as nasty-tasting as the opposite BHB salts I’ve tried
Thanks for the recommendation. I solely take Empagliflozin(10mg) and Rapa(2mg), however with the SGLT2 inhibitor I take it often and never every day(often after I know I will likely be consuming out or not the healthiest). I’ve not felt any uncomfortable side effects nor seen a drop in fasting glucose, though so far as I perceive SGLT2 inhibitors simply forestall the power of glucose from being reabsorbed, so undecided if I might anticipate a big drop in fasting glucose?
Thanks once more although, have you ever had any uncomfortable side effects in your expertise?
No, I had no uncomfortable side effects. I simply stopped taking it as a result of it didn’t appear to have any detectable impact on my fasting glucose ranges. It might have an effect on peak ranges, however I didn’t measure that.
Whether it is doing you some good I wouldn’t cease taking it.
You understand that your complete focus of sglt2 inhibitors is to blunt the height glucose ranges, and that’s what is regarded as the mechanism for all times extension within the NIA ITP research.
Fasting glucose wouldn’t be impacted.
See right here:
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After reviewing many articles, I’m extra bullish on SGLT-2 inhibitors than ever. They appear to proffer many cardiovascular and renal advantages, and a few of these could also be impartial of its glucose reducing actions.
See:
https://www.nature.com/articles/s41569-020-0406-8
- The cardiovascular advantages manifest quickly and are unlikely to be associated to the development in glycaemic management.
- Early natriuresis, reductions in plasma quantity, improved vascular resistance, lowered blood strain and modifications in tissue sodium dealing with would possibly underlie the fast discount within the threat of coronary heart failure.
- A shift in the direction of ketone physique metabolism, lowered serum uric acid ranges, lowered adipose tissue-mediated irritation, decreased oxidative stress and suppression of injury mediated by superior glycation end-products may additionally present profit.
https://journals.sagepub.com/doi/full/10.1177/1479164114559852
https://www.nature.com/articles/s41581-022-00535-6
SGLT2 inhibitors are constant throughout many affected person subgroups, together with these with and with out kind 2 diabetes, at completely different levels of CKD, and in sufferers with coronary heart failure with preserved or lowered ejection fraction.
This text talks in regards to the synergestic results of mixing GLP-1 RAs with SGLT-2 inhibitors, the place SGLT-2 inhibitors nonetheless do a lot of the heavy lifting.
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That stated, I nonetheless take it on an as wanted foundation, particularly an hour or so earlier than massive / carby meals, and don’t take it a lot after I’m following a ketogenic eating regimen or fasting.
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Thanks, I wasn’t actually conscious of the cardiovascular advantages for non-diabetics.
Since I’ve a yr’s provide of Jardiance from Boehringer Ingelheim Prescribed drugs guess I’ll begin taking it once more at a low dose. Many of the advantages cited are for kind 2 diabetics.
One of many results I missed till now could be the reducing of uric acid ranges.
This explains my sudden drop in uric acid ranges from my final blood take a look at.
“Empagliflozin was authorised for medical use in the US and within the European Union in 2014.[2][12][13][7] It’s on the World Well being Group’s Checklist of Important Medicines.[14] In 2019, it was the 146th mostly prescribed treatment in the US, with greater than 4 million prescriptions”
“Developed by
Boehringer Ingelheim Prescribed drugs and Eli Lilly and Firm”
Empagliflozin – Wikipedia.
I’ve been on the anti-aging quest for many years.
Whereas I’m no Michael Lustgarten, I comply with him on his Youtube channel “Conquer Growing old Or Die Attempting” Love his channel title, suits my purpose precisely.
I’m near acquiring the targets that I set for myself and now I’m simply performing some tweaking every so often. That’s the reason I’m right here; to learn from the data and expertise of others.
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Do you suppose uric acid drop will need to have been primarily as a result of empagliflozin? Had been you additionally taking quercetin within the meantime, for instance? Q additionally reduces uric acid.
Barely decrease uric acid just isn’t actually an issue no less than going by Rick Johnson’s work, and David Perlmutter additionally revealed a e book just lately with this thesis: Drop Acid: The Shocking New Science of Uric Acid – The Key to Dropping Weight, Controlling Blood Sugar and Attaining Extraordinary Well being – Kindle version by Perlmutter, David. Well being, Health & Weight-reduction plan Kindle eBooks @ Amazon.com.
Dr. Stanfield just about deatroys Perlmutter’s uric acid hypotheses within the video above. I haven’t regarded on the analysis myself, however he’s fairly convincing.
I’ve been taking quercetin for a really very long time. Possibly it has some synergistic impact. I’ll keep watch over it.
Thanks for the reference on uric acid.
After which I discovered this: Significance of serum uric acid ranges on the chance of all-cause and cardiovascular mortality – PubMed
This paper signifies that my uric acid stage could also be optimum, however it’s a small research.
It seems that the optimum stage of uric acid continues to be open for debate as there are a lot of conflicting research.
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Thanks for sharing this. Yeah I’m undecided how the dementia associated speculation stands.
But it surely seems like Rick Johnson is onto one thing essential with the position of fructose being dangerous, with lots of its results additionally being pushed by the manufacturing of uric acid, which has a job to play in kidney operate, hypertension, and so forth.
Maybe nobody is studying this thread, however what the hell…
I’m 2 weeks into Empagliflozin 10 mg for 1 week, then as much as 25 mg every day. I’m not precisely lightheaded, however comparable. I haven’t examined it, however I feel this can be just like what I’ve heard from athletes on a ketogenic eating regimen. It appears like I’ve barely much less blood sugar, so if I get used to this new power state, maybe I’ll adapt to this. In fact, that is wildly subjective and speculative. I don’t have a BG monitor round. I’m peeing extra, and my end-of-the-day leg swelling appears lowered.
It was studying about renoprotective results (I’ve endlessly had a barely elevated creatinine) and the cardiovascular reworking advantages which were postulated.
https://pubmed.ncbi.nlm.nih.gov/35320057/
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Dr. Stanfield didn’t current that drawback properly. Uric acid isn’t just an antioxidant it’s a prooxidant. There are suggestive pro-oxidative results of uric acid in CVD.
Hyperuricemia additionally might enhance the chance of hypertension, CKD, and better mortality of CHF. We all know these elements might enhance the general threat of dementia and there’s not sufficient to determine a causal line of proof, though there are just a few hints of it:
“Danger of dementia, particularly vascular or blended dementia, could also be elevated with excessive SUA ranges in aged folks.”
It may additionally simply be that it’s extra an indication of dehydration. Additionally, regular uric acid doesn’t rule out gout. Some folks can have concentrated uric acid to the purpose of saturation solely of their extremities.
Until one has a household historical past of gout and different threat elements (perhaps <5.8 can be higher), perhaps I’d take into account 5-6 being a doable goal purpose – however we don’t know for certain – might not matter in these ranges.
However, familial renal hypouricemia has an elevated threat of AKI, and recurrent AKI which ends up in CKD. So uric acid does have antioxidant capabilities which are essential when too low.
In the event you’re significantly , there are producer coupons for prescription CGM totally free 2 weeks of use for handy information assortment. I’d most likely shrink back from too many anti-hyperglycemic drugs (and infrequently sure meals) mixed directly though I don’t usually suppose hypoglycemia can be a priority for even a two-drug mixture of a lot of the medicine proposed right here on their very own.
I’ve elevated creatinine barely increased than regular probably from creatine monohydrate (Creapure) consumption and better than common lean mass. Each Cystatin C take a look at for years has been fully tremendous however eGFR all the time seems horrible on older creatinine-based calculations. It’s possible you’ll have an interest within the latest equations right here, simply in case:
I did a Cystatin C just lately within the excessive vary of NL. My creatine is the best way it’s as a result of I’m 6’ 6″, 247 lb and it’s largely muscle from sports activities; I additionally had a R quadriceps compartment syndrome in 2009, and the scar tissue continues more likely to preserve creatine excessive. I might be improper, However my BMI just isn’t a great way to evaluate my eGFR. However I used to be led to consider I had reasonable CKD for the longest time. I don’t consider it anymore.
I had heard it was a fable that Micronized Creatine Monohydrate Capsules may enhance creatinine, and I haven’t seen something that disputes this, however I stay open-minded. Thanks for the suggestion of CGM.
