I took one for the group and loaded 10mg of Siroboon on Friday morning then had my blood drawn 90 minutes later
May somebody assist me interpret?
6 Likes
Thanks a lot for posting!
20.6 ng/ML is sort of excessive… its undoubtedly stepping into your blood at a excessive stage!
Right here is the graph from a pattern of individuals at totally different dosing ranges of rapamycin:
And right here is the paper that helps you perceive the dose/response if you wish to dig deeper:
Extra Studying:
Pharmacokenetics and Security of a Single Dose of Rapamycin (sirolimus) in Wholesome Males
10.1097@00007691-200010000-00006-3.pdf (163.8 KB)
2 Likes
Nice to know – thanks. I imagine Siroboon is likely one of the least costly choices from the Indian pharmacies so good to see it really works.
I had take a previous dose of 2mg with grapefruit on the Sunday earlier than so there could have been some residual left from that however I don’t think about a lot
3 Likes
Interpretation requires a bit details about your dimension. That graph relies on sq. meters which is a metric for Physique Floor Space (BSA). BSA takes under consideration your peak in addition to your weight to normalize for various physique sorts. You possibly can calculate your BSA utilizing the calculator right here BSA Calculator – Physique Floor Space. For instance, I weigh about 75 kg and am 5’ 10″ tall so my BSA is ~ 2 m^2. I take 10 mg of sirolimus weekly so to seek out my place on that graph I’d comply with the 5 mg/ m^2 line. From the graph it seems to be like they discovered that on common individuals who took 5mg / m^2 had 35-40 ng /ml. If you’re about my peak and weight I’d conclude you might be barely low for that dose however that space of the graph is tough to interpret and you could be on both aspect of the height at 90 minutes submit ingestion (exhausting to say with out extra time factors). I’d say you might be about in step with what others have reported at that dose and relying in your BSA and timing it could be smack on what you’d anticipate.
5 Likes
Good, yeah my BSA is round 2.179
Wow! My ranges have been on 4.2 90 minutes after 4mg. Then .6 seven days later. Perhaps I must step up my recreation.
My Siroboon (10mg) end result. Surprisingly low (for me). Blood taken two hours after ingestion. Prior exams have been 40+ and 48+ ng/mL with Rapacan (additionally 10mg). All three exams carried out in the identical NC lab.
I suppose I’ll follow the Rapacan I’ve for now, and do extra Siroboon testing another time.
My batch has ‘Jan 2023’ manufacture date. @forceofnature what does yours say?
Len – so this check you simply posted above is whenever you used siroboon model of sirolimus? What dose stage? Every other attainable variables you possibly can consider which may have differed out of your different exams with Biocon Rapacan?
I up to date the unique submit to reply a few of your questions.
The Siroboon (10mg) above was the primary dosing after stopping for 2 weeks.
The 2 Rapacan exams have been after weekly build up, 1,2,3,5,7, after which 10mg (check), and following week 10mg (check).
However these totally different contexts shouldn’t matter, proper? After per week, focus must be down round/beneath 1ng/mL.
No distinction in meals consumed prior. All three exams inside 10 minutes or so of round two hours elapsed time after preliminary ingestion. Although Siroboon was in all probability the longest elapsed time, however nonetheless not way more than two hours.
In idea, sure. However individuals do course of rapamycin in another way, so there could have been some vital ranges of rapamycin nonetheless in your system after taking 10mg, and ready for per week, then taking the subsequent 10mg. (vs. 10mg after a two week break). The one approach to make sure is testing trough ranges simply earlier than you dose once more.
The one approach to make sure is for me to begin a sirolimus testing gofundme 
1 Like
