As anticipated and calculated, I contacted Pfizer and so they instructed me Rapamune has a bioavailability of 17% and nano coating makes it extra water soluble, their oral answer 14% and Biocon Rapacan instructed me their Rapamycin has an absorption charge of 15%.
There’s solely 2% distinction and Rapamune is extra water soluble. Should you take Rapacan with fatty meal, it needs to be much more bioavailable. If we think about that Rapamune is 3 instances costlier, let’s do that:
As a substitute of taking, for instance, 6mg Rapamune, which you soak up 1.02mg Sirolimus, take 7mg Rapacan and also you soak up 1.05mg Sirolimus.
What do you consider this?
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Leo,
That is actually good data and I applaud your efforts to truly contact the drug firms and get the small print. This data is nice to have.
Your assumptions and logic all appear very sound.
My solely caveat can be that we nonetheless have near zero understanding of what the optimum dosing for rapamycin in longevity for people is, so placing an excessive amount of consideration into whether or not its 6mg or 7mg, whereas useful, maybe shouldn’t be the most important concern we face 
Now we have fairly numerous folks right here utilizing rapamycin with grapefruit juice or grapefruit (entire) and seeing outcomes of elevated blood/sirolimus ranges of wherever from 0% (a number of store-purchased pasturized GFJ dont’ appear to extend bioavailability in any respect) to 500% or greater – so if somebody is taking 3mg with GFJ they might be getting wherever from 3mg to 15mg equal dosing.
However – for individuals who wish to monitor intently their true rapamycin dosing, and its impact on their physique, I believe that is nice data.
Thanks for sharing!
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Thanks.
6mg was simply an instance.
I needed to emphasise the concept there may be solely 2% distinction between Pfizer and Biocon whereas the value distinction is greater than 200%.
That’s an attention-grabbing comparability. One other giant and largely unknown issue is how particular person the absorption charge is. In response to at the very least one knowledgeable quoted on this discussion board, the absorption charge is very variable by particular person.
Get a snapshot of your degree, peak and trough. That is the most affordable check I’ve seen. I’m making an attempt it quickly because it has been about 8 months since I’ve examined and I’ve a brand new model, Biocon, now:
