What was your lightbulb second w/ Rapamycin? – rapamycin

A variety of people right here appeared to first hear of rapamycin by way of Peter Attia’s podcast, David Sinclair’s e-book Lifespan, or a selected scientific paper. I wish to hear your origin tales.

What was your lightbulb second once you lastly understood and needed to strive rapamycin?

How did you first turn out to be rapa-“pilled”? (no pun supposed)

I first got here throughout rapamycin whereas researching metformin. I heard Vitalik speak about taking metformin and the way he thought it was a 50-50 probability of extending your life, so might as properly give it a shot.

After some primary Googling, I got here throughout Peter Attia’s look on the Tim Ferriss Podcast the place he defined why he was extra bullish on rapa than metformin. That led me to learn the mice research and ultimately to this discussion board!

For me it was the Blagosklonny article 3 years in the past… taking a look at longevity data on-line:

Hyperlink: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/

“In case you wait till you might be prepared, it’s virtually actually too late.”

I made a decision to not wait! Been on it 2.5 years… no regrets. All higher…organic age 15 to twenty years youthful than chronological age. Lifting increased weights, pores and skin improved… reminiscence wonderful… fixed euphoria.

I first heard about it from David Sinclair e-book, however I used to be bummed out as a result of it had so many unwanted effects, as David talked about. The lightbulb second was seeing Peter Attia mentioning he was taking it weekly, avoiding or decreasing mentioned unwanted effects.

I noticed somebody submit about Rapamycin on a Reddit longevity subreddit (I believe it might need been @desertshores or @Krister_Kauppi ), I cyber-stalked them till I discovered this discussion board, after which learn every thing I might right here about Rapamycin. Appeared a good suggestion to start out experimenting with Rapamycin myself.

I had been listening to in regards to the early mouse research on rapamycin within the mid, to late 2000s and later, so sooner or later I added a “google alert” for rapamycin (I do that for any fascinating compound that’s within the longevity house). However all of the damaging information round immune suppression tempered my enthusiasm. Someday after 2010 (perhaps round 2014) I noticed an article that quoted Matt Kaeberlein saying that maybe by dosing weekly quite than repeatedly would get across the immune supression subject. Then in 2019 I noticed the MensHealth article come up in my google alerts and after studying it and performing some extra analysis determined I needed to strive it – so began taking rapamycin quickly after that article.

Precisely… after studying Blagosklonny…I discovered that Males’s Well being article three completely different aged males and every had a rapamycin story.

That undoubtedly clinched it for me.

Despatched each articles to my private doctor. We mentioned it . . no actual unhealthy unwanted effects… simply cease utilizing if it doesn’t work. I used to be prescribed rapamycin one month later.

I first heard it from Peter Attia. I got here to him eager to be taught extra about fasting, and acquired hooked on his podcasts about rapamycin.

I first heard about it from Sinclairs Lifespan. Nonetheless, it was Dr. Stanfield who led me right here. And all of you fantastic folks right here clinched the deal.

A buddy of mine did a podcast about rapamycin and his expertise taking it in December of ‘22 and that acquired me excited about studying extra. It appeared fairly serendipitous.