Which dietary supplements are good for ALMOST EVERYONE?

After watching the newest Matt Kaberlein video, I spotted that many people are taking a bunch of dietary supplements, which can or will not be appropriate for everybody. I needed to start out this matter in order that we may shortlist these small molecules that ALMOST EVERYONE needs to be taking for improved well being and why we expect so. Then the remainder of us can play satan’s advocate till we get a really tight listing of common suggestions for supplementation. I’ll begin it off

1. Rapamycin – Who wouldn’t need an additional 30% lifespan? It extends life in virtually all trials for all mannequin organisms (at the least 64 research achieved!) It’s a senomorphic and prevents senescence. Throughout finest life-extending small molecule that we’re conscious of now.

2. Vitamin D3 – 50% of individuals have a deficiency and for those who do have a deficiency you’re more likely to get COVID. COVID wreaks havoc in your physique and reduces lifespan. When you have a D3 deficiency, this results in higher all-cause mortality.
   Efficacy and Security of Vitamin D Supplementation to Forestall COVID-19 in Frontline Healthcare Employees. A Randomized Medical Trial – ScienceDirect

3. Omega 3s – (with EPA 2x that of the DHA) Confirmed coronary heart well being advantages. Helps decrease dangerous ldl cholesterol (counters among the results of Rapamycin on ldl cholesterol). Reduces blood stress and most cancers threat and different indicators of ageing.
   13 Well being Advantages Of Omega 3 Fatty Acids (Backed By Science) – Lifehack

4. Magnesium – Magnesium performs many essential roles within the physique, reminiscent of supporting muscle and nerve perform and power manufacturing.
   Professionals and cons of taking a magnesium complement – Mayo Clinic.

5. Glycine – ITP exhibits a 5% elevated lifespan when taken. It helps clear methionine from the physique. It helps glutathione manufacturing together with NAC. No downsides that I’m conscious of. It additionally tastes great.
   Glycine supplementation extends lifespan of female and male mice – PubMed

I might add K2 to your listing.

I take K2 myself, however why would you add it?

I take vit K2 along with D3 to advertise bone metabolism amongst different issues.

Melatonin, as a result of an excellent nights sleep is the healthiest factor you possibly can present your physique

creatine, that’s probably the most researched and most confirmed efficacious complement there may be. It’s low cost and really secure too (and no it doesn’t trigger kidney illness or harm kidney perform ever)

I might take omega-3 of that listing, omega-3 is one thing it is advisable to get from complete meals, not a rancid capsule

My listing:
creatine
magnesium
nutritional vitamins d3/k2 combo

Sure, creatine is a should for prevention of sarcorpenia.

I’m battling the issue of taking too many dietary supplements. My purpose is simply to maintain the listing to 10 or fewer. Proper now I nonetheless have a cabinet filled with dietary supplements. After all, I don’t take all of them on any given day.

I might add to your listing:

Metformin: “metformin may very well gradual ageing and enhance life expectancy by enhancing the physique’s responsiveness to insulin, antioxidant results, and enhancing blood vessel well being.Sep 29, 2021 (Is metformin a surprise drug? – Harvard Well being)

Creatine: “The advantages afforded to older adults by means of creatine ingestion are substantial, can enhance high quality of life, and in the end might scale back the illness burden related to sarcopenia and cognitive dysfunction.”
“Not too long ago, creatine has been discovered to considerably decrease the buildup of a acknowledged marker of ageing referred to as lipofuscin within the brains of ageing mice. Because of this, creatine-fed mice lived a median of 9% longer than management animals” (Use of creatine within the aged and proof for results on cognitive perform in younger and outdated – PubMed) (Creatine Reduces Markers Of Getting older – Life Extension Urology of Virginia)

I preserve listening to that omega-3 fish oil dietary supplements are not any good as a result of they’re rancid due to oxidation.

Nevertheless, it happens to me that no oil oxidation can happen if it’s not uncovered to oxygen.

So, please inform me how the oil in hermetically sealed capsules is meant to oxidize.

The capsules are undoubtedly not hermetically sealed and neither are the containers particularly after opening. I want canned cod liver or soused herring (Dutch specialty do exhausting to get elsewhere) for omega 3

And but, there are quite a few research displaying the advantages of fish oil dietary supplements.

Have been these research that confirmed advantages utilizing recent product? I believe so.

However there even have been advances in stabilizing encapsulated fish oil. I’m unable to search out out if there may be particular processing or stabilizers added to the merchandise we purchase. If that’s the case, I havent seen it talked about on a label.

Does anybody have a contact with a fish oil processing firm that might shed some gentle on this?

The perfect useful resource to search out out concerning the high quality of dietary supplements is Labdoor.com. They evaluation and charge dietary supplements together with fish oil.

Right here’s the report on the one I exploit:

And the consumerlab.com evaluations instructed most fish oils are wonderful, and never rancid.

I feel I’ve come to appreciate that in comparison with Rapamycin, all the opposite dietary supplements are simply noise when it comes to longevity. I’ve already began to pare again on those I’m re-ordering. I’m actually going to scrutinize which of them are actually value it or not.

I dumped all my pink yeast rice dietary supplements final evening. Extra to comply with. Maverick shall be proud.

Omega 3 complement examine outcomes are actually a combined bag of excellent outcomes and no outcomes and as stated even when the dietary supplements are good while you purchase them they may go rancid when you open them. Strive chewing your capsules and style them, good omega 3 oil will style creamy and buttery with no fishy aftertaste style

Selenium needs to be thought-about on your stack. Frankly, if I had to decide on between omega3 supplementation and selenium, I might go for selenium

Through the years of studying many articles concerning the well being advantages of many dietary supplements, I’ve gathered a cabinet filled with dietary supplements, a lot of which I don’t take on daily basis or solely take sometimes for particular circumstances.
I acquired on to selenium with Coq10 from some article that I don’t even keep in mind and have been taking them faithfully on daily basis, solely as a result of they occurred to be within the entrance of the cabinet.

Now I see that the advantages could also be extra necessary than I assumed. That is necessary to me due to the battle between sustaining a high-protein weight-reduction plan beneficial for the aged and methionine restriction.

I’ve it to enhance tooth, bones and to decalcify blood vessels

I agree. Selenium was lined in fairly some depth on this dialogue. Vadim recommends two brazil nuts a day for selenium.

I consider one Brazil nut a day will meet your selenium necessities. Just like the OP I used to be shocked by Matt Kaberlein’s feedback. I really like his no bullshit perspective and he’s proper, the complement trade is rife with salesmenship. Take into account, although, that he’s a scientist and he’s solely taking a look at issues that reach lifespan. Whereas many on this discussion board have related aspirations, dietary supplements produce other legitimate makes use of. I feel there may be consensus that it’s very exhausting to fulfill your magnesium necessities with complete meals as a result of farmland has been stripped of it by overfarming. Adele Davis used to say that the human physique was like a sponge and it may be barely moist or filled with water. Like many right here I most likely take too many dietary supplements out of an abundance of warning that my weight-reduction plan is insufficient. I’m planning on doing a Genova Metobolom check to see precisely what i’d want. Query: how can pure oil squeezed out of a cod not style fishy? And why is that equated with dangerous? It have to be extremely processed to haven’t any style.

Canned cod liver isn’t processed in any respect aside from the canning and possibly heating the (sealed) cans. It actually doesn’t style fishy all, neither does recent soused herring however as soon as ready it begins to go dangerous actually quick. Good recent herring tastes creamy and silty like the ocean however for those who preserve it ready within the fridge even, it begins going dangerous very quick inside hours they may get a fishy (however not in an excellent sense) style