Is anybody accustomed to his work? He takes dietary supplements I’ve not heard of here’s a excerpt from a submit I discovered on Quora:
Lithium salts have a facet impact, which is that it damages the kidney . Is there a approach to cut back the negative effects of lithium salts?In accordance with associated analysis, N-Acetylcysteine ameliorates lithium-induced renal failure in rats.
(I often take lithium with glutathione, NAC, glycine and betaine to guard liver and kidney )
In accordance with A triple drug mixture concentrating on elements of the nutrient-sensing community maximizes longevity, rapamycin remedy leads to insulin resistance and dyslipidemia in sufferers and mice, and this disturbance manifests as hypertriglyceridemia in Drosophila. Lithium reversed this and the hunger resistance related to rapamycin remedy. On this research, double mixtures of lithium and rapamycin, lithium and trametinib, or rapamycin and trametinib produced a reproducibly higher lifespan extension than controls, on common 30%, in comparison with every compound alone, which prolonged lifespan by a mean of 11%. Remarkably, the triple drug mixture elevated lifespan by 48%.
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Can we now take lithium, trametinib, and rapamycin collectively?
As
FWIW within the US a prescription of 2mg of Trametinib {Mekinist] 30 pill is round $13,050.00 with a reduction coupon {17% off the typical retail worth of $15,826.00
The India model is just ₹72,000 round $870.00 USD
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And as a facet impact it clears up any melanomas you might need.
This appears to be the research he primarily based his routine on:
https://www.pnas.org/doi/10.1073/pnas.1913212116
A triple drug mixture concentrating on elements of the nutrient-sensing community maximizes longevity
Jorge Iván Castillo-Quan ORCID, Luke S. Tain, Kerri J. Kinghorn, +5, and Linda Partridge
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There isn’t any assurance{that trametinib/mekinist]
will “clears up any melanomas”.
Hooked up is a PDF copy of the paper.
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$870 per dose? Cheapo me will strive the pure various.
Cranberries are the very best supply, however mg content material is minuscule. So I’ll strive the complement. Amazon sells 100mg myricetin tabs for $20 per 60 tabs.
Trametinib is a MEK inhibitor, and so is myricetin.
2mg of Trametinib {Mekinist] 30 tablets
From India $870.00
A US stuffed prescription $13,050.00. The typical retail value within the US is $15,826.00*
*Novartis is have a tough time, they should get well all their value.
Okay. $29 per dose, versus $20 per bottle of myricetin. Proof to date, is on flies. I’ll follow the cheapo shot.
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If remedy of most cancers is the goal, not longevity, combining with modified rice bran could also be stronger.
That research had just one affected person.
“In a now 59 years previous affected person with inoperable (BRAF-mutant) low differentiated adenocarcinoma of bilary ducts after 30GY radiotherapy and two cycles (Gemcitabin+ Cisplatin) chemotherapy a speedy development of lung, liver and mind metastases had been by CT and MR established. Thereafter, a teatment with BRAF+MEK inhibitors (2×150 mg dabrafenib and 1 x 2 mg trametinib) was began. These inhibitors had been mixed with each day 45 mg/kg rice bran arabinoxylan focus (utilizing Biobran/MGN-3) which was proven to be a pathogenic related molecular sample (PAMP)-like molecule and might stimulate the type-1 innate immune cells towards tumor cells.”
“Outcomes: After the chemotherapy and previous to the beginning of second line remedy, the affected person had a virtually terminal state of her quickly progressive illness. Eight months after the mixture of MEK / BRAF inhibitor and immunomodulator remedy practically full remissions of all metastases was established in CT and MR.”
People, I believe that no person ought to be taking a complement routine primarily based on leads to flies…
From the paper talked about above…
“additively to extend longevity in Drosophila
Please don’t begin taking medication and dietary supplements primarily based on all these outcomes… its fascinating, however we’d like much more proof in mammals earlier than contemplating it.
Geroscientists on the current longevity summit had been discussing (and rolling their eyes) concerning the loopy biohackers that make selections on dietary supplements or medication primarily based on drosophila (fly) or c.elegans (worm) analysis. Don’t be a type of individuals please.
Most fly and worm research outcomes don’t translate to people.
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Thanks for the warning. Myricetin being a flavanol like quercetin and fisetin, I consider it’s a secure guess.
With regard to subbing for trametinib, it seems to be like myricetin, independently, has been examined on the identical drosophila flies.
“Myricetin has been famous to extend common (18%) and maximal (21.7%) lifespan in C. Elegans , which was a efficiency higher than different examined flavanols (quercetin, kaempferol, and naringenin) related to lowering oxidative harm to the mitochondrial and proteins;[19] when examined in mev-1(kn1) mutants (lowered lifespan[20] related to larger mitochondrial oxidative stress[21]) all flavonoids lowered mitochondrial oxidative stress (in a fashion not associated to DAF-16 translocation) but solely myricetin elevated common lifespan (16%) in these mutants.”
It seems to be like consuming a handful of cranberries is ample for supplementation, primarily based on the desk beneath.
Cranberries, 6600 mg per 100 grams.
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JuanDaw,
You trial/expermention will likely be rapamycin and cranberry?
Cranberry to repeat trametinib?
Or rapamycin, cranberry and lithium?
One other skunk works!
Reference the paper submit in the beginning of this thread;
In accordance with the paper; hunger seems to be the best way to go. 
Lithium orotate seems to be the most secure approach to take a lithium salt and it’s accessible with out a prescription due to its security.
FWIW: I’ve been taking lithium orotate for many years with no in poor health results.
“These outcomes are supportive of the dearth of a postmarket security sign from a number of a long time of human consumption.”
BTW: These had been slightly large doses.
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I’ve not taken any anti-aging medication but. I’ll strive 1) capers (substitute for rapamycin – has extra affinity to Everolimus), 2) myricetin complement or cranberries (trametinib substitute), and three) lithium.
The docking research assist Kaempferol to be a possible ligand with docking rating values of 33.4 (3CQU-3D construction of AKT1)] and 27.3 (2FAP-3D construction of FRB area of mTOR) respectively as in comparison with that of ordinary drug Everolimus with 24.4 (3CQU-3D construction of AKT1) and 20.1 (2FAP-3D construction of FRB area of mTOR) respectively. Docking research together with ADMET outcomes exhibits that Kaempferol has favorable drug likeliness properties and bind to the identical lively website (site1) of the focused proteins (3CQU-3D construction of AKT1) and (2FAP-3D construction of FRB area of mTOR) the place the usual drug Everolimus is understood to bind. Conclusion The research exhibited that Kaempferol was having a greater binding affinity in the direction of the receptor FKBP12, a Rapamycin Binding Area and AKT serine/threonine-protein kinase leading to its higher efficacy within the mTORC1 inhibition as when put next with commonplace drug Everolimus towards HCC.
Capers have the very best degree of kaempferol.
It simply received dried capers in salt two days in the past. Rinsed them a number of occasions, to take away the salt, and soaked them in a single day for good measure. Dried them in a dehydrator. Ready for the myricetin to reach in two days. Lithium? I’m poking round to seek out out an acceptable dosage.
I plan to take it three days per week. Most individuals right here take rapamycin as soon as per week. Due to the half-life, the rapa, most likely stays within the physique about three to 4 days. Myricetin has a half life of 11 hours. However kaempferol has a half lifetime of solely 3-4 hours. I’ve to plan a extra frequent dosing, perhaps BID or TID.
