I’ve coated hair regeneration analysis by Yokohama Nationwide College (Japan) based mostly scientist Dr. Junji Fukuda a couple of instances previously. His group’s most vital work pertains to hair multiplication by way of the manufacturing of hair follicle germs.
Nevertheless, Dr. Fukuda achieved world notoriety in 2018 as a result of French Fries chemical associated hair loss “treatment”. Lately, the Yokohama Crew has printed quite a few papers. Furthermore, they plan to start hair multiplication trials in people in 2023. I replace this put up often as a result of significance I connect to Dr. Fukuda’s work. Make certain to additionally test Fukuda Lab for the most recent information.
October 21, 2022
The un-finalized paper that I discussed in my prior June replace was simply launched as we speak. A number of media protection.
In one more breakthrough, the Yokahama College group led by Junji Fukuda and Tatsuto Kageyama have managed to develop mature mice hair follicles in cultures. Precise paper right here and was printed as we speak. The information is already being coated extensively in quite a few publications, together with US Information and Yahoo.
In accordance with Newscientist:
Mature hair follicles have been grown in a laboratory for the primary time, in a transfer that would in the future deal with hair loss.
The hair follicles grew for as much as one month, reaching 3 millimetres size. In accordance with Dr. Fukuda, that is most likely on account of the truth that the mice hair cycle is about one month. Quote from the great physician:
Our subsequent step is to make use of cells from human origin, and apply for drug growth and regenerative medication.
Additionally be aware that the identical group launched a new paper on October 1 titled: “Impacts of manipulating cell sorting on in vitro hair follicle regeneration.”
June 25, 2022
The updates from Dr. Fukuda and his group at Yokohama Nationwide College (YNU) hold coming and I’m excited. Due to “Ben” for the hyperlinks to the 2 newest papers. Additionally be certain to see Dr. Fukuda’s patents web page.
Junji Fukuda and TrichoSeeds
- On June 16, the Fukuda Lab printed a brand new paper titled: “Bioprinting of hair follicle germs for hair regenerative medication.” This examine outlines an strategy for the scalable and automatic preparation of extremely hair-inductive grafts utilizing a bioprinter (picture above). The examine hyperlink additionally consists of two attention-grabbing movies on the backside.
Nevertheless, maybe of most curiosity to me, they declare within the paper that:
“Ayaka Nanmo, Tatsuto Kageyama and Junji Fukuda are co-founders of TrichoSeeds, an organization that gives hair regeneration medication.”
This confirms the unique YNU announcement about TrichoSeeds from earlier this 12 months that quite a few readers mentioned.
- Additionally printed in June 2022 (however not but peer-reviewed), the Fukuda and Kageyama group authored a paper titled: “Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction.”
Whereas doing analysis for this replace, I found the beneath new April 2022 video printed by Yokohama Nationwide College with regard to Dr. Fukuda. This all appears to be the true deal….though I mentioned the identical previously in regards to the Dr. Tsuji/Riken group. Additionally see this earlier 2017 video presentation from Dr. Fukuda.
Replace: April 15, 2022
Yokohama College and Dr. Junji Fukuda
I contemplate Dr. Fukuda and his group to be among the many 5 most vital gamers on this planet which might be engaged on a hair loss treatment. Per final 12 months’s information (see additional beneath), the Yokohama group plans to start out human scientific trials in 2023.
On this newest analysis, the group managed to make new hair that was at first solely rising beneath the pores and skin of mice to sprout by way of the pores and skin. They did this by way of using guide-inserted hair microgels (HMGs). They conclude:
“This strategy is a promising technique to advance hair regenerative medication.”
Replace: April 7, 2021
Interview with Dr. Tatsuto Kageyama
Yesterday, in our Discord chat, “DrPhil” posted a hyperlink to a new April interview with Dr. Tatsuto Kageyama of Yokohama Nationwide College. It’s price a full learn.
After some fast analysis, I spotted that Dr. Kageyama is a co-author in Dr. Fukuda’s vital 2019 paper titled: “Preparation of hair beads and hair follicle germs for regenerative medication.”
This newest interview with Dr. Kageyama is extraordinarily insightful and inspiring.
Human Trials to Begin in 2023
A very powerful information is that human trials will begin in 2023. Furthermore, the remedy won’t be too expensive, and it will likely be secure.
Some key quotes after translation:
“We began fundamental analysis utilizing human cells in 2018, aiming to start out scientific trials in 2023. And we’re working laborious along with the members of the laboratory in order that we will ship it to everybody as quickly as potential.”
“We additionally imagine that we can resolve price points.”
Apparently, they’re satisfied that the price of this remedy will probably be a lot decrease compared to different regenerative medication remedies. A pleasant change from Dr. Tsuji’s costly hair loss treatment.
The group’s mass tradition know-how doesn’t necessitate costly tools. Furthermore, the required quantity of hair follicle primordia may be produced with a single tradition container.
Hair Follicle Primordium Creation
The Yokohama Nationwide College group’s hair multiplication course of includes creating hair follicle primordia. Epithelial cells and mesenchymal cells combine to type a tissue referred to as “hair follicle primordium“. That is primarily the seed for hair development.
The method this group makes use of entails:
- Extract a couple of wholesome scalp hairs.
- Improve the “epithelial cells” and “mesenchymal cells” that exist in these follicles.
- Thereafter, domesticate a considerable amount of hair follicle primordia.
- Transplant these new cells to balding areas of the donor’s scalp to regenerate the hair.
It will likely be potential to provide hundreds of hairs from a number of hairs. The entire course of is taken into account to be secure as a result of autologous nature of the remedy.
Japan and Regenerative Medication
Better of all, in Japan, scientific trials in regenerative medication are anticipated to maneuver alongside quicker than within the US or EU. The nation has a quickly getting older society with low delivery charges. Due to this fact, it’s a world chief in anti-aging associated analysis.
The vital triumvirate of Riken (Tsuji), Shiseido, and Yokohama (Fukuda) are all based mostly in Japan. I’m very hopeful that at the least one in all these three will lastly reach bringing a subsequent technology hair loss remedy or treatment to the market.
