Evidently rapamycin could also be contra-indicated for some folks with sure well being circumstances, and I needed to get peoples ideas on this and assist construct a listing in order to boost consciousness. Are there different circumstances that individuals have come throughout which may make rapamycin inadvisable?
For instance – this research appears to counsel that individuals who have diabetes might not profit from rapamycin, and may be harmed:
We examined the impact of rapamycin on the life span of a mouse mannequin of sort 2 diabetes, db/db mice. At 4 months of age, female and male C57BLKSJ-lepr db/dbmice (db/db ) have been positioned on both a management eating regimen, missing rapamycin or a eating regimen containing rapamycin and maintained on these diets over their life span. Rapamycin was discovered to scale back the life span of the db/db mice. The median survival of male db/db mice fed the management and rapamycin diets was 349 and 302 days, respectively, and the median survival of feminine db/db mice fed the management and rapamycin diets was 487 and 411 days, respectively. Adjusting for gender variations, rapamycin elevated the mortality danger 1.7-fold in each female and male db/db mice. Finish-of-life pathological knowledge confirmed that suppurative irritation was the principle explanation for dying within the db/db mice, which is enhanced barely by rapamycin therapy.
1 Like
Flawed research.
Begins rapamycin at 4 months of age, equal to a human 13 yr outdated.
They did a trial with a special pressure of mice on the similar time additionally beginning at 4 months of age the place rapamycin did enhance lifespan
2 Likes
No – that shouldn’t have an effect on the lifespan of the mice. Harvard’s Gladyshev lab did a research final yr the place they began giving rapamycin instantly after beginning for 45 days and the mice lived longer and have been more healthy:
1 Like
My unhealthy, you two are proper. I ought to’ve learn additional than the summary.
I wouldn’t have thought that rapamycin would enhance the lifespan of mice given at such a younger age. 
1 Like
